Enhancement of rI n :rC n -Induced Interferon Production by Amphotericin B

Author:

Borden Ernest C.1,Leonhardt Peggy H.1

Affiliation:

1. Division of Clinical Oncology, Departments of Human Oncology and Medicine, University of Wisconsin Center for Health Sciences, Madison, Wisconsin 53706

Abstract

When mouse L929 cells are treated with amphotericin B before exposure to polyriboinosinic-polyribocytidylic acid or polyriboinosinic-polyribocytidylic acid-dextran, they make significantly more interferon than do cells not receiving amphotericin. This effect may be due to enhanced cell membrane penetration by the polynucleotide.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference25 articles.

1. Sensitivity to amphotericin B of in vitro established cell lines;Amati P.;Nature (London),1974

2. On the anatomy of amphotericin B-cholesterol pores in lipid bilayer membranes;Andreoli T. E.;Kidney Int.,1973

3. Cell interaction with a synthetic polynucleotide and interferon production in vitro;Bausek G. H.;Virology,1969

4. The interferon refractory state. II. Biological characterization of a refractoriness inducing protein;Borden E. C.;J. Immunol.,1975

5. The specificity of interferon induction in chick embryo cells by helical RNA;Colby C.;Proc. Natl. Acad. Sci. U.S.A.,1969

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