Isolation and Propagation of Human Papillomavirus Type 16 in Human Xenografts Implanted in the Severe Combined Immunodeficiency Mouse-Reference-Cited by-同舟云学术

Isolation and Propagation of Human Papillomavirus Type 16 in Human Xenografts Implanted in the Severe Combined Immunodeficiency Mouse

Published:1998-06 Issue:6 Volume:72 Page:5256-5261
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bonnez William¹,DaRin Carrie¹,Borkhuis Christine¹,de Mesy Jensen Karen²,Reichman Richard C.¹,Rose Robert C.¹

Affiliation:

1. Departments of Medicine1 and

2. Pathology,2 University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

Abstract

ABSTRACT We report the isolation and propagation of human papillomavirus type 16, the main agent of cervical cancer, using human foreskin fragments implanted in severe combined immunodeficiency mice. The infection produced viral particles, and with each passage of the virus it caused lesions identical to intraepithelial neoplasia, the precursor to carcinoma.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.6.5256-5261.1998

Reference44 articles.

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4. Bonnez W. Unpublished data.

5. Bonnez W. Borkhuis C. DaRin C. de Mesy Jensen K. L. Beutner K. Van Nest G. Greer C. Growth and propagation of human papillomavirus (HPV) type 6 in the human skin xenograft-severe combined immunodeficiency (SCID) mouse model Abstracts of the 15th International Papillomavirus Workshop Gold Coast Queensland Australia 1996 152

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