Synergistic Activities of Three Triazoles with Caspofungin against Candida glabrata Isolates Determined by Time-Kill, Etest, and Disk Diffusion Methods-Reference-Cited by-同舟云学术

Synergistic Activities of Three Triazoles with Caspofungin against Candida glabrata Isolates Determined by Time-Kill, Etest, and Disk Diffusion Methods

Published:2010-05 Issue:5 Volume:54 Page:2244-2247
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kiraz Nuri¹,Dag Ilknur²,Yamac Mustafa³,Kiremitci Abdurrahman¹,Kasifoglu Nilgun¹,Oz Yasemin¹

Affiliation:

1. Department of Microbiology, Medical Faculty

2. Health Services Vocational High School

3. Department of Biology, Faculty of Art and Science, University of Eskisehir Osmangazi, Eskisehir, Turkey

Abstract

ABSTRACT Combinations of voriconazole, fluconazole, and itraconazole with caspofungin were evaluated against 50 Candida glabrata isolates by the time-kill, disk diffusion, and Etest methods. The majority of antifungal combinations were indifferent. By the time-kill method, synergistic activity was detected with eight (16%) of the caspofungin-voriconazole and seven (14%) of the caspofungin-fluconazole combinations, but synergy was not seen with the caspofungin-itraconazole combination. Further comparisons of the Etest and disk diffusion synergy techniques with the time-kill method are warranted.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01527-09

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