In Vitro Activity of ACH-702, a New Isothiazoloquinolone, against Nocardia brasiliensis Compared with Econazole and the Carbapenems Imipenem and Meropenem Alone or in Combination with Clavulanic Acid-Reference-Cited by-同舟云学术

In Vitro Activity of ACH-702, a New Isothiazoloquinolone, against Nocardia brasiliensis Compared with Econazole and the Carbapenems Imipenem and Meropenem Alone or in Combination with Clavulanic Acid

Published:2010-05 Issue:5 Volume:54 Page:2191-2193
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vera-Cabrera Lucio¹,Campos-Rivera Mayra Paola¹,Escalante-Fuentes Wendy G.¹,Pucci Michael J.²,Ocampo-Candiani Jorge¹,Welsh Oliverio¹

Affiliation:

1. Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Monterrey, N.L., México

2. Achillion Pharmaceuticals, Inc., 300 George Street, New Haven, Connecticut 06511

Abstract

ABSTRACT The in vitro activities of ACH-702 and other antimicrobials against 30 Nocardia brasiliensis isolates were tested. The MIC 50 (MIC for 50% of the strains tested) and MIC 90 values of ACH-702 were 0.125 and 0.5 μg/ml. The same values for econazole were 2 and 4 μg/ml. The MIC 50 and MIC 90 values of imipenem and meropenem were 64 and >64 μg/ml and 2 and 8 μg/ml, respectively; the addition of clavulanic acid to the carbapenems had no effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01520-09

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