Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo-Reference-Cited by-同舟云学术

Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo

Published:2006-05-15 Issue:10 Volume:188 Page:3721-3725
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Dheenadhayalan Veerabadran¹,Delogu Giovanni²,Sanguinetti Maurizio²,Fadda Giovanni²,Brennan Michael J.¹

Affiliation:

1. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland

2. Institute of Microbiology, Catholic University of the Sacred Heart, Rome, Italy

Abstract

ABSTRACT Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis . Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.188.10.3721-3725.2006

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