Classical Swine Fever Virus Leader Proteinase N pro Is Not Required for Viral Replication in Cell Culture-Reference-Cited by-同舟云学术

Classical Swine Fever Virus Leader Proteinase N pro Is Not Required for Viral Replication in Cell Culture

Published:1998-09 Issue:9 Volume:72 Page:7681-7684
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tratschin Jon-Duri¹,Moser Christian¹,Ruggli Nicolas¹,Hofmann Martin A.¹

Affiliation:

1. Institute of Virology and Immunoprophylaxis, CH-3147 Mittelhäusern, Switzerland

Abstract

ABSTRACT The sequence encoding the viral leader proteinase N pro was replaced by the murine ubiquitin gene in a full-length cDNA clone of the classical swine fever virus (CSFV) strain Alfort/187. The recombinant virus vA187-Ubi showed growth characteristics similar to those of the parent vA187-1 virus. At two occasions cells infected with vA187-Ubi exhibited a cytopathic effect and were found to contain a subgenomic viral RNA. This RNA lacked the same viral genes as the subgenomic RNA which has been found in all cytopathogenic CSFV strains analyzed so far, but it maintained the ubiquitin sequence.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.9.7681-7684.1998

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