Interference with Pseudomonas aeruginosa Quorum Sensing and Virulence by the Mycobacterial Pseudomonas Quinolone Signal Dioxygenase AqdC in Combination with the N -Acylhomoserine Lactone Lactonase QsdA-Reference-Cited by-同舟云学术

Interference with Pseudomonas aeruginosa Quorum Sensing and Virulence by the Mycobacterial Pseudomonas Quinolone Signal Dioxygenase AqdC in Combination with the N -Acylhomoserine Lactone Lactonase QsdA

Published:2019-10 Issue:10 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Birmes Franziska S.¹,Säring Ruth¹,Hauke Miriam C.¹,Ritzmann Niklas H.¹,Drees Steffen L.¹,Daniel Jens²,Treffon Janina³,Liebau Eva²,Kahl Barbara C.³^ORCID,Fetzner Susanne¹^ORCID

Affiliation:

1. Institute for Molecular Microbiology and Biotechnology, University of Münster, Münster, Germany

2. Institute for Animal Physiology, University of Münster, Münster, Germany

3. Institute of Medical Microbiology, Münster University Hospital, Münster, Germany

Abstract

The nosocomial pathogen Pseudomonas aeruginosa regulates its virulence via a complex quorum sensing network, which, besides N -acylhomoserine lactones, includes the alkylquinolone signal molecules 2-heptyl-3-hydroxy-4(1 H )-quinolone ( Pseudomonas quinolone signal [PQS]) and 2-heptyl-4(1 H )-quinolone (HHQ). Mycobacteroides abscessus subsp. abscessus , an emerging pathogen, is capable of degrading the PQS and also HHQ. Here, we show that although M. abscessus subsp.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00278-19

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