H 2 S, a Bacterial Defense Mechanism against the Host Immune Response-Reference-Cited by-同舟云学术

H 2 S, a Bacterial Defense Mechanism against the Host Immune Response

Published:2019-01 Issue:1 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Toliver-Kinsky Tracy¹²,Cui Weihua¹,Törö Gabor¹,Lee Seung-Jin¹,Shatalin Konstantin³,Nudler Evgeny³,Szabo Csaba¹²⁴

Affiliation:

1. Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, USA

2. Shriners Hospitals for Children, Galveston, Texas, USA

3. Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA

4. Chair of Pharmacology, Department of Medicine, University of Fribourg, Fribourg, Switzerland

Abstract

The biological mediator hydrogen sulfide (H 2 S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H 2 S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections, Escherichia coli and Staphylococcus aureus .

Funder

HHS | National Institutes of Health

Howard Hughes Medical Institute

U.S. Department of Defense

Shriners Hospitals for Children

Blavatnik Family Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00272-18