Meropenem-Clavulanic Acid Has HighIn VitroActivity against Multidrug-Resistant Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Meropenem-Clavulanic Acid Has HighIn VitroActivity against Multidrug-Resistant Mycobacterium tuberculosis

Published:2015-03-30 Issue:6 Volume:59 Page:3630-3632
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Davies Forsman L.^ORCID,Giske C. G.,Bruchfeld J.,Schön T.,Juréen P.,Ängeby K.

Abstract

ABSTRACTWe investigated the activity of meropenem-clavulanic acid (MEM-CLA) against 68Mycobacterium tuberculosisisolates. We included predominantly multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) isolates, since the activity of MEM-CLA for resistant isolates has previously not been studied extensively. Using Middlebrook 7H10 medium, all but four isolates showed an MIC distribution of 0.125 to 2 mg/liter for MEM-CLA, below the non-species-related breakpoint for MEM of 2 mg/liter defined by EUCAST. MEM-CLA is a potential treatment option for MDR/XDR-TB.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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