In Vitro Activity of the Quinolone WCK 771 against Recent U.S. Hospital and Community-Acquired Staphylococcus aureus Pathogens with Various Resistance Types

Author:

Bhagwat Sachin S.1,McGhee Pamela2,Kosowska-Shick Klaudia2,Patel Mahesh V.1,Appelbaum Peter C.2

Affiliation:

1. Wockhardt Research Center, Aurangabad, India 431210

2. Hershey Medical Center, Hershey, Pennsylvania 17033

Abstract

ABSTRACT WCK 771 demonstrated MIC 50 and MIC 90 s of 0.03 and 1 μg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus , irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC 90 s of WCK 771 and moxifloxacin were 1 and 16 μg/ml, respectively.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference17 articles.

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4. Ferrero, L., B. Cameron, B. Manse., D. Lagneaux, J. Crouzet, A. Famechon, and F. Blanche. 1994. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol.4:651-653.

5. In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor

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