Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis-Reference-Cited by-同舟云学术

Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Miller William R.¹²^ORCID,Singh Kavindra V.¹²,Arias Cesar A.¹²³⁴⁵,Murray Barbara E.¹²³

Affiliation:

1. Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, McGovern Medical School, Houston, Texas, USA

2. Department of Internal Medicine, Division of Infectious Diseases, UTHealth, McGovern Medical School, Houston, Texas, USA

3. Department of Microbiology and Molecular Genetics, UTHealth, McGovern Medical School, Houston, Texas, USA

4. Center for Infectious Diseases, UTHealth, School of Public Health, Houston, Texas, USA

5. Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia

Abstract

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log 10 CFU/g) compared to that with cefazolin alone (2 ± 0.6 log 10 CFU/g; P < 0.0001).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01158-18

Reference18 articles.

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