Mononuclear and Polymorphonuclear Leukocyte Dispositions of Clarithromycin and Azithromycin in AIDS Patients Requiring Mycobacterium avium Complex Prophylaxis-Reference-Cited by-同舟云学术

Mononuclear and Polymorphonuclear Leukocyte Dispositions of Clarithromycin and Azithromycin in AIDS Patients Requiring Mycobacterium avium Complex Prophylaxis

Published:1999-09 Issue:9 Volume:43 Page:2302-2304
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bui Khanh Q.¹,McNabb JoCarol¹,Li Chonghua¹,Nightingale Charles H.²,Nicolau David P.¹³

Affiliation:

1. Department of Pharmacy Research,1

2. Department of Research Administration,2 and

3. Department of Medicine, Division of Infectious Diseases,3Hartford Hospital, Hartford, Connecticut 06102

Abstract

ABSTRACT The intracellular dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex (MAC) prophylaxis were studied. The dispositions of both drugs in mononuclear and polymorphonuclear leukocytes were markedly different. Our data support the proven efficacy of these agents for MAC prophylaxis since clarithromycin and azithromycin displayed sustained intracellular concentrations which exceeded their MICs for MAC throughout the dosing periods.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.43.9.2302

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