A New SARS-CoV-2 Dual-Purpose Serology Test: Highly Accurate Infection Tracing and Neutralizing Antibody Response Detection

Author:

Taylor Sean C.1ORCID,Hurst Beth2,Charlton Carmen L.345ORCID,Bailey Ashley3,Kanji Jamil N.36,McCarthy Mary K.7,Morrison Thomas E.7,Huey Leah89,Annen Kyle1011,DomBourian Melkon G.1011,Knight Vijaya89

Affiliation:

1. GenScript USA Inc., Piscataway, New Jersey, USA

2. Cayman Chemical, Ann Arbor, Michigan, USA

3. Public Health Laboratory, Alberta Precision Laboratories (ProvLab), University of Alberta Hospital, Edmonton, AB, Canada

4. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

5. Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada

6. Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, AB, Canada

7. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA

8. Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA

9. Department of Pediatrics, Children’s Hospital Colorado Anschutz Medical Campus, Aurora, Colorado, USA

10. Department of Pathology and Laboratory Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA

11. Department of Pathology and Laboratory Medicine, Children’s Hospital Colorado Anschutz Medical Campus, Aurora, Colorado, USA

Abstract

Many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology tests have proven to be less accurate than expected and do not assess antibody function as neutralizing, correlating with protection from reinfection. A new assay technology measuring the interaction of the purified SARS-CoV-2 spike protein receptor binding domain (RBD) with the extracellular domain of the human angiotensin-converting enzyme 2 (hACE2) receptor detects these important antibodies.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference43 articles.

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4. COVID-19 Testing

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