Author:
Zhang Ying,Jiang Xiaofei,Wang Yanyan,Li Gang,Tian Yueru,Liu Hong,Ai Fuqi,Ma Yiming,Wang Bei,Ruan Feiyi,Rajakumar Kumar
Abstract
ABSTRACTFifty-seven carbapenem-resistantKlebsiella pneumoniaeisolates belonging to ST11 (50 isolates), ST423 (5 isolates), and two other sequence types were studied. All were positive forblaKPC-2,blaTEM-1, andblaCTX-M-14. SDS-PAGE analysis of six representative isolates demonstrated varied porin expression. Nevertheless, whenblaKPC-2was deleted, carbapenem resistance was markedly reduced. Additionally, SHV-12, DHA-1, and/or VIM-1 appeared to contribute to accessory carbapenemase activity. In contrast, OmpK35 and/or OmpK36 deficiency seemed to serve only as a minor cooperative factor.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
55 articles.
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