Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa

Published:2020-03-24 Issue:4 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ben Jeddou Fatma¹²,Falconnet Léna¹²,Luscher Alexandre¹²,Siriwardena Thissa³,Reymond Jean-Louis³,van Delden Christian¹²,Köhler Thilo¹²

Affiliation:

1. Transplant Infectious Diseases Unit, University Hospitals Geneva, Geneva, Switzerland

2. Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland

3. Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

Abstract

Colistin (polymyxin E) is a last-resort antibiotic against multidrug-resistant isolates of Pseudomonas aeruginosa . However, the nephro-toxicity of colistin limits its use, spurring the interest in novel antimicrobial peptides (AMP). Here, we show that the synthetic AMP-dendrimer G3KL (MW 4,531.38 Da, 15 positive charges, MIC = 8 mg/liter) showed faster killing than polymyxin B (Pmx-B) with no detectable resistance selection in P. aeruginosa strain PA14.

Funder

Swiss National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02040-19

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