Affiliation:
1. JMI Laboratories, North Liberty, Iowa, USA
2. University of Iowa, Iowa City, Iowa, USA
Abstract
ABSTRACT
The activity of CD101 and comparator antifungal agents against 606 invasive fungal isolates collected worldwide during 2014 was evaluated using the Clinical and Laboratory Standards Institute (CLSI) method. All
Candida albicans
(
n
= 251),
Candida tropicalis
(
n
= 51),
Candida krusei
(
n
= 16), and
Candida dubliniensis
(
n
= 11) isolates were inhibited by ≤0.12 μg/ml of CD101 and were susceptible or showed wild-type susceptibility to the other echinocandins tested. Five
C. glabrata
isolates (
n
= 100) displayed CD101 MIC values of 1 to 4 μg/ml, had elevated MICs of caspofungin (2 to >8 μg/ml), anidulafungin (2 to 4 μg/ml), and micafungin (2 to 4 μg/ml), and carried mutations on
fks1
and
fks2
.
Candida parapsilosis
(
n
= 92) and
Candida orthopsilosis
(
n
= 10) displayed higher CD101 MIC values (ranges, 0.5 to 4 μg/ml and 0.12 to 2 μg/ml, respectively), and similar results were observed for the other echinocandins tested. Fluconazole resistance was noted among 11.0% of
Candida glabrata
isolates, 4.3% of
C. parapsilosis
isolates, and 2.0% of
C. albicans
and
C. tropicalis
isolates. The activity of CD101 against
Aspergillus fumigatus
(
n
= 56) was similar to that of micafungin and 2-fold greater than that of caspofungin but less than that of anidulafungin. These isolates had wild-type susceptibility to itraconazole, voriconazole, and posaconazole. The echinocandins had limited activity against
Cryptococcus neoformans
(
n
= 19). CD101 was as active as the other echinocandins against common fungal organisms recovered from patients with invasive fungal infections. The long half-life profile is very desirable for the prevention and treatment of serious fungal infections, especially in patients who can then be discharged from the hospital to complete antifungal therapy on an outpatient basis.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
45 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献