Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing-Reference-Cited by-同舟云学术

Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Martinez-Hernandez J. Eduardo¹²³⁴^ORCID,Hammoud Zaynab⁵^ORCID,de Sousa Alessandra Mara⁶,Kramer Frank⁵^ORCID,Monte-Neto Rubens L. do⁶^ORCID,Maracaja-Coutinho Vinicius³⁷⁴^ORCID,Martin Alberto J. M.²⁸^ORCID

Affiliation:

1. Programa de Doctorado en Genómica Integrativa, Vicerrectoría de Investigación, Universidad Mayor, Santiago, Chile

2. Laboratorio de Biología de Redes, Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Santiago, Chile

3. Advanced Center for Chronic Diseases - ACCDiS, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile

4. Centro de Modelamiento Molecular, Biofísica y Bioinformática – CM2B2, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile

5. IT-Infrastructure for Translational Medical Research, University of Augsburg, Augsburg, Germany

6. Biotecnologia Aplicada ao Estudo de Patógenos - Instituto René Rachou – Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil

7. Instituto Vandique, João Pessoa, Brazil

8. Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Santiago, Chile

Abstract

This work opens a new path to fight parasites by targeting host molecular functions by repurposing available and approved drugs. We created a novel approach to identify key proteins involved in any biological process by combining gene regulatory networks and expression profiles.

Funder

Bundesministerium für Bildung und Forschung

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico

Universidad de Chile

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01018-21