Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients

Author:

Grønseth Stine1ORCID,Rogne Tormod23,Hannula Raisa4,Åsvold Bjørn Olav567,Afset Jan Egil18,Damås Jan Kristian149

Affiliation:

1. Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway

2. Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway

3. Department of Chronic Disease Epidemiology, Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA

4. Department of Infectious Diseases, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway

5. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Trondheim, Norway

6. HUNT Research Center, Department of Public Health and Nursing, NTNU, Levanger, Norway

7. Department of Endocrinology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway

8. Department of Medical Microbiology, St. Olavs hospital, Trondheim University Hospital, Trondheim, Norway

9. Centre of Molecular Inflammation Research, NTNU, Trondheim, Norway

Abstract

Pneumocystis jirovecii is potentially life threatening to an increasing number of individuals with compromised immune systems. This microorganism can cause severe pneumonia in susceptible hosts, including patients with cancer and autoimmune diseases and people undergoing solid organ transplantation.

Funder

Norges Forskningsråd

Norges Teknisk-Naturvitenskapelige Universitet

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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