Interplay of OpdP Porin and Chromosomal Carbapenemases in the Determination of Carbapenem Resistance/Susceptibility in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Interplay of OpdP Porin and Chromosomal Carbapenemases in the Determination of Carbapenem Resistance/Susceptibility in Pseudomonas aeruginosa

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Atrissi Jad¹,Milan Annalisa¹,Bressan Raffaela¹,Lucafò Marianna²,Petix Vincenzo²,Busetti Marina³,Dolzani Lucilla¹,Lagatolla Cristina¹^ORCID

Affiliation:

1. Department of Life Sciences, University of Trieste, Trieste, Italy

2. Institute for Maternal and Child Health—IRCCS Burlo Garofolo, Trieste, Italy

3. Microbiology Unit, University Hospital of Trieste, Trieste, Italy

Abstract

This study examines the interplay of multiple factors in determining a pattern of resistance or susceptibility to carbapenems in clinical isolates of Pseudomonas aeruginosa , focusing on the role of previously poorly understood determinants. In particular, the impact of carbapenem permeability through OprD and OpdP porins was analyzed, as well as the activity of the chromosomal carbapenemases AmpC and PoxB, going beyond the simple identification of resistance determinants encoded by each isolate.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01186-21

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