Unique Gut Microbiome in HIV Patients on Antiretroviral Therapy (ART) Suggests Association with Chronic Inflammation-Reference-Cited by-同舟云学术

Unique Gut Microbiome in HIV Patients on Antiretroviral Therapy (ART) Suggests Association with Chronic Inflammation

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ishizaka Aya¹²,Koga Michiko¹,Mizutani Taketoshi¹²,Parbie Prince Kofi³,Prawisuda Diki¹,Yusa Nozomi⁴,Sedohara Ayako¹,Kikuchi Tadashi³⁵,Ikeuchi Kazuhiko⁵,Adachi Eisuke⁵,Koibuchi Tomohiko⁵,Furukawa Yoichi⁴,Tojo Arinobu⁶,Imoto Seiya⁷,Suzuki Yutaka⁸,Tsutsumi Takeya¹,Kiyono Hiroshi²,Matano Tetsuro³⁹^ORCID,Yotsuyanagi Hiroshi¹⁵

Affiliation:

1. Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, The University of Tokyo, Tokyo, Japan

2. International Research and Development Center for Mucosal Vaccines, the Institute of Medical Science, The University of Tokyo, Tokyo, Japan

3. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

4. Department of Applied Genomics, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

5. Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, The University of Tokyo, Tokyo, Japan

6. Department of Laboratory Medicine, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

7. Division of Health Medical Data Science, Health Intelligence Center, the Institute of Medical Science, The University of Tokyo, Tokyo, Japan

8. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

9. Department of AIDS Vaccine Development, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

Chronic inflammation is a hallmark of HIV infection and is associated with the development and progression of age-related comorbidities. Although the gastrointestinal tract is a major site of HIV replication and CD4 + T-cell depletion, the role of HIV-associated imbalance of gut microbiome in chronic inflammation is unclear.

Funder

Japan Agency for Medical Research and Development

MEXT | JST | Science and Technology Research Partnership for Sustainable Development

MEXT | Japan Science and Technology Agency

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00708-21

Reference47 articles.

1. Long-Term Mortality in HIV-Infected Individuals 50 Years or Older