Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model-Reference-Cited by-同舟云学术

Caerin 1.1 and 1.9 Peptides from Australian Tree Frog Inhibit Antibiotic-Resistant Bacteria Growth in a Murine Skin Infection Model

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chen Shu¹,Zhang Pingping¹,Xiao Liyin¹,Liu Ying¹,Wu Kuihai²,Ni Guoying³⁴,Li Hejie³,Wang Tianfang³,Wu Xiaolian¹,Chen Guoqiang⁴,Liu Xiaosong¹³^ORCID

Affiliation:

1. Cancer Research Institute, Foshan First People’s Hospital, Foshan, Guangdong, China

2. Clinical Microbiological Laboratory, Foshan First People’s Hospital, Foshan, Guangdong, China

3. Genecology Research Centre, University of the Sunshine Coast, Maroochydore, QLD, Australia

4. Department of Rheumatology, Foshan Frist People’s Hospital, Foshan, Guangdong, China

Abstract

Antibiotic-resistant bacteria cause severe problems in the clinic. We show in our paper that two short peptides isolated from an Australian frog and prepared in the form of a gel are able to inhibit the growth of antibiotic-resistant bacteria in mice, and, unlike antibiotics, these peptides do not lead to the development of peptide-resistant bacteria strains.

Funder

National Natural Science Foundation of China

Dengfeng Project of Foshan First People’s Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00051-21

Reference39 articles.

1. Bacterial Skin and Soft Tissue Infections in Adults: A Review of Their Epidemiology, Pathogenesis, Diagnosis, Treatment and Site Of Care

2. Cellulitis incidence in a defined population