SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis-Reference-Cited by-同舟云学术

SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Panigrahi Soumya¹,Goswami Tamal²,Ferrari Brian¹,Antonelli Christopher J.¹,Bazdar Douglas A.¹,Gilmore Hannah³,Freeman Michael L.¹,Lederman Michael M.¹,Sieg Scott F.¹

Affiliation:

1. Division of Infectious Diseases and HIV Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

2. Department of Chemistry, Raiganj University, Raiganj, West-Bengal, India

3. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Abstract

SARS-CoV-2 causes complex effects on microvascular homeostasis that potentially contribute to organ dysfunction and coagulopathies. SARS-CoV-2 binds to, and causes downregulation of angiotensin converting enzyme 2 (ACE2) on cells that it infects.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00735-21

Reference58 articles.

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4. SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells

5. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

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