Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin-Reference-Cited by-同舟云学术

Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Galván Adriana E.¹^ORCID,Paul Ngozi P.¹^ORCID,Chen Jian¹,Yoshinaga-Sakurai Kunie¹,Utturkar Sagar M.²,Rosen Barry P.¹^ORCID,Yoshinaga Masafumi¹^ORCID

Affiliation:

1. Department of Cellular Biology and Pharmacology, Florida International University, Herbert Wertheim College of Medicine, Miami, Florida, USA

2. Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA

Abstract

Antimicrobial resistance is an emerging global public health crisis, calling for urgent development of novel potent antibiotics. We propose that arsinothricin and related arsenic-containing compounds may be the progenitors of a new class of antibiotics to extend our antibiotic era.

Funder

National Science Foundation

HHS | National Institutes of Health

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00502-21

Reference39 articles.

1. Purification and characterization of the respiratory arsenate reductase of Chrysiogenes arsenatis