Gene Amplification Uncovers Large Previously Unrecognized Cryptic Antibiotic Resistance Potential in E. coli

Author:

Suarez Stacy A.1ORCID,Martiny Adam C.12ORCID

Affiliation:

1. Department of Ecology and Evolutionary Biology, University of California, Irvine, California, USA

2. Department of Earth System Science, University of California, Irvine, California, USA

Abstract

Predicting where new antibiotic resistance genes will rise is a challenge and is especially important when new antibiotics are developed. Adaptive resistance allows sensitive bacterial cells to become transiently resistant to antibiotics.

Funder

National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference72 articles.

1. Antibiotic resistance threats in the United States;US CDC.;Centers Dis Control Prev,2019

2. The antibiotic resistance crisis: causes and threats;Ventola CL;P T,2015

3. O’Neil J. 2014. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. Review on antibiotic resistance, London, United Kingdom.

4. Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

5. Nonoptimal Gene Expression Creates Latent Potential for Antibiotic Resistance

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