SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

Author:

Deere Jesse D.1ORCID,Carroll Timothy D.23,Dutra Joseph1,Fritts Linda2,Sammak Rebecca Lee3,Yee JoAnn L.3,Olstad Katherine J.3,Reader J. Rachel3,Kistler Amy4,Kamm Jack4,Di Germanio Clara5,Shaan Lakshmanappa Yashavanth2,Elizaldi Sonny R.2,Roh Jamin W.2,Simmons Graham56,Watanabe Jennifer3,Pollard Rachel E.3,Usachenko Jodie3,Immareddy Ramya3,Schmidt Brian A.2,O’Connor Shelby L.78,DeRisi Joseph49,Busch Michael P.56,Iyer Smita S.2310,Van Rompay Koen K. A.310ORCID,Hartigan-O’Connor Dennis J.13,Miller Christopher J.231011

Affiliation:

1. Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California, USA

2. Center for Immunology and Infectious Diseases, University of California Davis, Davis, California, USA

3. California National Primate Research Center, University of California Davis, Davis, California, USA

4. Chan Zuckerberg Biohub, San Francisco, California, USA

5. Vitalant Research Institute, San Francisco, California, USA

6. Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA

7. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA

8. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA

9. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA

10. Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, Davis, California, USA

11. Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, University of California Davis, Davis, California, USA

Abstract

Antiviral treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain very limited. One treatment that was explored beginning early in the pandemic (and that is likely to be tested early in future pandemics) is plasma collected from people who have recovered from coronavirus disease 2019 (COVID-19), known as convalescent plasma (CP).

Funder

George Mason University

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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