Affiliation:
1. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom
Abstract
Antibiotics inhibit essential bacterial processes, resulting in arrest of growth and, in some cases, cell death. Many antibiotics are also reported to trigger endogenous production of reactive oxygen species (ROS), which damage DNA, leading to induction of the mutagenic SOS response associated with the emergence of drug resistance. However, the type of DNA damage that arises and how this triggers the SOS response are largely unclear.
Funder
NIHR Imperial Biomedical Research Centre
Shionogi
UKRI | Medical Research Council
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
13 articles.
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