Increased Expression of Efflux Pump <i>norA</i> Drives the Rapid Evolutionary Trajectory from Tolerance to Resistance against Ciprofloxacin in Staphylococcus aureus-Reference-Cited by-同舟云学术

Increased Expression of Efflux Pump norA Drives the Rapid Evolutionary Trajectory from Tolerance to Resistance against Ciprofloxacin in Staphylococcus aureus

Published:2022-12-20 Issue:12 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yu X. H.¹,Hao Z. H.¹,Liu P. L.¹,Liu M. M.¹,Zhao L. L.¹,Zhao X.¹²^ORCID

Affiliation:

1. College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, People’s Republic of China

2. Department of Animal Science, McGill University, Montreal, Quebec, Canada

Abstract

The intensively intermittent use of antibiotics promotes the rapid evolution of tolerance, which may lead to resistance acquisition in the following evolutionary trajectory. In addition to directly exporting antibiotics as an instant resistance strategy, efflux pumps are overexpressed in tolerant strains.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00594-22

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