Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium-Reference-Cited by-同舟云学术

Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium

Published:2021-01-25 Issue:2 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Horiuchi Makoto¹²,Taguchi Keiko¹³⁴^ORCID,Hirose Wataru¹²,Tsuchida Kouhei¹,Suzuki Mikiko⁵,Taniyama Yusuke²,Kamei Takashi²,Yamamoto Masayuki¹³⁴^ORCID

Affiliation:

1. Department of Medical Biochemistry, Tohoku University, Sendai, Japan

2. Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan

3. Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan

4. Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan

5. Center for Radioisotope Sciences, Tohoku University, Sendai, Japan

Abstract

Nrf2 is essential for cytoprotection against carcinogens, and through systemic Nrf2 knockout mice, Nrf2-deficient cells were shown to be susceptible to chemical carcinogens and prone to developing cancers. However, the oncogenic potential of Nrf2-deficient epithelial cells surrounded by normal cells in the esophagus could not be assessed by previous models, and the fate of Nrf2-deficient cells in such situations remains elusive.

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

MEXT | JST | Core Research for Evolutional Science and Technology

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00536-20

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1. The KEAP1–NRF2 System in Cancer