Macrophage Depletion Prior to Neospora caninum Infection Results in Severe Neosporosis in Mice-Reference-Cited by-同舟云学术

Macrophage Depletion Prior to Neospora caninum Infection Results in Severe Neosporosis in Mice

Published:2014-05-28 Issue:8 Volume:21 Page:1185-1188
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin. Vaccine Immunol.

Author:

Abe Chisa,Tanaka Sachi,Ihara Fumiaki,Nishikawa Yoshifumi

Abstract

ABSTRACTWe observed that murine macrophages showed greater activation and increased interleukin 6 (IL-6), IL-12p40, and interferon gamma (IFN-γ) production duringNeospora caninuminfection. Many macrophages migrated to the site of infection. Furthermore, macrophage-depleted mice exhibited increased sensitivity toN. caninuminfection. This study indicates that macrophages are required for achieving protective immunity againstN. caninum.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Reference16 articles.

1. Unidentified cyst-forming sporozoon encephalomyelitis and myositis in dogs;Bjerkås;Z Parasitenkd.,1984

2. Newly recognized fatal protozoan disease of dogs;Dubey;J. Am. Vet. Med. Assoc.,1988

3. Epidemiology and control of neosporosis and Neospora caninum;Dubey;Clin. Microbiol. Rev.,2007

4. Interferon-gamma and interleukin-12 mediate protection to acute Neospora caninum infection in BALB/c mice;Baszler;Int. J. Parasitol.,1999

5. In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophages;Nishikawa;Clin. Diagn. Lab. Immunol.,2001

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