Differential Recognition of Plasmodium falciparum Merozoite Surface Protein 2 Variants by Antibodies from Malaria Patients in Brazil-Reference-Cited by-同舟云学术

Differential Recognition of Plasmodium falciparum Merozoite Surface Protein 2 Variants by Antibodies from Malaria Patients in Brazil

Published:2003-09 Issue:5 Volume:10 Page:973-976
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Kanunfre Kelly A.¹,Leoratti Fabiana M. S.¹,Hoffmann Erika H. E.²,Durlacher Rui R.³⁴,Ferreira Antônio W.¹,Moraes-Ávila Sandra L.¹,Ferreira Marcelo U.²

Affiliation:

1. Institute of Tropical Medicine of São Paulo

2. Department of Parasitology, Institute for Biomedical Sciences

3. Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo

4. Center for Research in Tropical Medicine (CEPEM), Porto Velho, Brazil

Abstract

ABSTRACT Four variants of merozoite surface protein 2 (MSP-2) of Plasmodium falciparum were used in serology to examine whether changes in repeat units affect its recognition by antibodies during infection with parasites of known MSP-2 types. The results indicate that variation in MSP-2 repeats may represent a mechanism for parasite immune evasion.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.10.5.973-976.2003

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