Interleukin 12 in Part Regulates Gamma Interferon Release in Human Whole Blood Stimulated with Leptospira interrogans-Reference-Cited by-同舟云学术

Interleukin 12 in Part Regulates Gamma Interferon Release in Human Whole Blood Stimulated with Leptospira interrogans

Published:2003-03 Issue:2 Volume:10 Page:332-335
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

de Fost Maaike¹²³,Hartskeerl Rudy A.¹²³,Groenendijk Martijn R.¹²³,van der Poll Tom¹²³

Affiliation:

1. Laboratory of Experimental Internal Medicine

2. Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam

3. WHO/FAO Collaborating Centre for Reference and Research on Leptospirosis, Royal Tropical Institute, Amsterdam, The Netherlands

Abstract

ABSTRACT Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-γ) and the IFN-γ-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-γ was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.10.2.332-335.2003

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5. Differentiation of Pathogenic and Saprophytic Leptospires I. Growth at Low Temperatures

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