Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells-Reference-Cited by-同舟云学术

Acute Viral Escape Selectively Impairs Nef-Mediated Major Histocompatibility Complex Class I Downmodulation and Increases Susceptibility to Antiviral T Cells

Published:2016-02-15 Issue:4 Volume:90 Page:2119-2126
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Weiler Andrea M.¹,Das Arpita²,Akinyosoye Oluwasayo²,Cui Sherry³,O'Connor Shelby L.¹⁴,Scheef Elizabeth A.²,Reed Jason S.⁵,Panganiban Antonito T.²⁶,Sacha Jonah B.⁵⁷,Rakasz Eva G.¹,Friedrich Thomas C.¹⁸,Maness Nicholas J.²⁶

Affiliation:

1. Wisconsin National Primate Research Center, Madison, Wisconsin, USA

2. Division of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA

3. Biomedical Sciences Training Program, Tulane University, New Orleans, Louisiana, USA

4. Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, USA

5. Division of Pathobiology and Immunology, Oregon National Primate Research Center, Oregon Health and Sciences University, Portland, Oregon, USA

6. Department of Microbiology and Immunology, School of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA

7. Vaccine & Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Sciences University, Portland, Oregon, USA

8. Department of Pathobiological Sciences, University of Wisconsin, Madison, Wisconsin, USA

Abstract

ABSTRACT Nef-specific CD8 + T lymphocytes (CD8TL) are associated with control of simian immunodeficiency virus (SIV) despite extensive nef variation between and within animals. Deep viral sequencing of the immunodominant Mamu-B*017:01-restricted Nef 165–173 IW9 epitope revealed highly restricted evolution. A common acute escape variant, T 170 I, unexpectedly and uniquely degraded Nef's major histocompatibility complex class I (MHC-I) downregulatory capacity, rendering the virus more vulnerable to CD8TL targeting other epitopes. These data aid in a mechanistic understanding of Nef functions and suggest means of immunity-mediated control of lentivirus replication.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01975-15

Reference43 articles.

1. Comprehensive Immunological Evaluation Reveals Surprisingly Few Differences between Elite Controller and Progressor Mamu-B*17 -Positive Simian Immunodeficiency Virus-Infected Rhesus Macaques

2. Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques

3. Patterns of CD8 + Immunodominance May Influence the Ability of Mamu - B * 08 -Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication