The C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a-Reference-Cited by-同舟云学术

The C-Terminal Domains of the PB2 Subunit of the Influenza A Virus RNA Polymerase Directly Interact with Cellular GTPase Rab11a

Published:2022-03-09 Issue:5 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Veler Hana¹²,Fan Haitian¹,Keown Jeremy R.³,Sharps Jane¹,Fournier Marjorie⁴,Grimes Jonathan M.²³,Fodor Ervin¹^ORCID

Affiliation:

1. Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

2. Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, United Kingdom

3. Division of Structural Biology, University of Oxford, Oxford, United Kingdom

4. Advanced Proteomics Facility, Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Abstract

The influenza virus RNA genome segments are replicated in the cell nucleus and are assembled into viral ribonucleoprotein (vRNP) complexes with viral RNA polymerase and nucleoprotein (NP). Replicated vRNPs need to be exported from the nucleus and trafficked across the cytoplasm to the cell membrane, where virion assembly takes place.

Funder

UKRI | Medical Research Council

Wellcome Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01979-21

Reference50 articles.

1. Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

2. At the centre: influenza A virus ribonucleoproteins