Cyclic AMP Directly Activates NasP, an N -Acyl Amino Acid Antibiotic Biosynthetic Enzyme Cloned from an Uncultured β-Proteobacterium-Reference-Cited by-同舟云学术

Cyclic AMP Directly Activates NasP, an N -Acyl Amino Acid Antibiotic Biosynthetic Enzyme Cloned from an Uncultured β-Proteobacterium

Published:2007-09 Issue:17 Volume:189 Page:6487-6489
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Clardy Jon¹,Brady Sean F.²

Affiliation:

1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave., Boston, Massachusetts 02115

2. Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10021

Abstract

ABSTRACT The cyclic AMP (cAMP)-dependent biosynthesis of N -acylphenylalanine antibiotics by NasP, an environmental DNA-derived N -acyl amino acid synthase, is controlled by an NasP-associated cyclic nucleotide-binding domain and is independent of the global cAMP signal transducer, cAMP receptor protein. A 16S rRNA gene sequence found on the same environmental DNA cosmid as NasP is most closely related to 16S sequences from β-proteobacteria.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00457-07

Reference26 articles.

1. Environmental Whole-Genome Amplification To Access Microbial Populations in Contaminated Sediments

2. Cyclic AMP in prokaryotes

3. Brady, S. F. 2007. Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules. Nat. Protocols 2 : 1297-1305.

4. Long-Chain N -Acyltyrosine Synthases from Environmental DNA

5. Brady, S. F., C. J. Chao, and J. Clardy. 2002. New natural product families from an environmental DNA (eDNA) gene cluster. J. Am. Chem. Soc. 124 : 9968-9969.

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