Infectivity of Cryptosporidium hominis and Cryptosporidium parvum Genotype 2 Isolates in Immunosuppressed Mongolian Gerbils-Reference-Cited by-同舟云学术

Infectivity of Cryptosporidium hominis and Cryptosporidium parvum Genotype 2 Isolates in Immunosuppressed Mongolian Gerbils

Published:2005-08 Issue:8 Volume:73 Page:5252-5255
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Baishanbo Asiya¹,Gargala Gilles¹,Delaunay Agnès²,François Arnaud³,Ballet Jean-Jacques²,Favennec Loïc¹

Affiliation:

1. Laboratoire de Parasitologie, and ADEN EA-3234, CHU Charles Nicolle, Rouen, France

2. Laboratoire d'Immunologie et d'Immunopathologie, UPRES EA-2128, CHU Clemenceau, Caen, France

3. Laboratoire d'Histopathologie, CHU Charles Nicolle, Rouen, France

Abstract

ABSTRACT One-month-old dexamethasone-immunosuppressed Mongolian gerbils were challenged with 1 oocyst to 2 × 10 5 oocysts from two isolates genotyped as Cryptosporidium hominis and C. parvum (genotype 2), respectively. A similar dose-dependent gut infection was obtained, and the initial genotype maintained for 21 to 22 days. The data suggest that immunosuppressed gerbils provide a reliable rodent model of persistent C. hominis infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.8.5252-5255.2005

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