Characterization of a Humanized Monoclonal Antibody Recognizing Clumping Factor A Expressed by Staphylococcus aureus-Reference-Cited by-同舟云学术

Characterization of a Humanized Monoclonal Antibody Recognizing Clumping Factor A Expressed by Staphylococcus aureus

Published:2005-08 Issue:8 Volume:73 Page:5229-5232
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Domanski Paul J.¹,Patel Pratiksha R.¹,Bayer Arnold S.²,Zhang Li¹,Hall Andrea E.¹,Syribeys Peter J.¹,Gorovits Elena L.¹,Bryant Dawn¹,Vernachio John H.¹,Hutchins Jeff T.¹,Patti Joseph M.¹

Affiliation:

1. Inhibitex, Inc., Alpharetta, Georgia

2. LA Biomedical Research, Torrance, California

Abstract

ABSTRACT We report the humanization and characterization of monoclonal antibody (MAb) T1-2 or tefibazumab, a monoclonal antibody that recognizes clumping factor A expressed on the surface of Staphylococcus aureus . We demonstrate that the binding kinetics of MAb T1-2 is indistinguishable compared to that of its murine parent. Furthermore, MAb T1-2 is shown to enhance the opsonophagocytic uptake of ClfA-coated latex beads, protect against an intravenous challenge in a prophylactic model of rabbit infective endocarditis, and enhance the efficacy of vancomycin therapy in a therapeutic model of established infective endocarditis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.8.5229-5232.2005

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