Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori In Vitro and In Vivo-Reference-Cited by-同舟云学术

Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori In Vitro and In Vivo

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Luo Peipei¹²³⁴⁵,Huang Yanqiang¹²³⁵⁶,Hang Xudong¹²³⁵,Tong Qian¹²³⁵,Zeng Liping¹²³⁵,Jia Jia¹²³⁵,Zhang Guoxin⁴⁵,Bi Hongkai¹²³⁵^ORCID

Affiliation:

1. Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China

2. Jiangsu Key Laboratory of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, China

3. Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

4. Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

5. Helicobacter pylori Research Center, Nanjing Medical University, Nanjing, Jiangsu, China

6. Research Center for the Prevention and Treatment of Drug Resistant Microbial Infection, Youjiang Medical University for Nationalities, Baise, Guangxi, China

Abstract

Helicobacter pylori is a major global pathogen and has been implicated in gastritis, peptic ulcer, and gastric carcinoma. The efficacy of the extensive therapy of H. pylori infection with antibiotics is compromised by the development of drug resistance and toxicity toward human gut microbiota, which urgently demands novel and selective antibacterial strategies.

Funder

Jiangsu Specially Appointed Professor of China

Jiangsu Medical Specialist Program of China

National Science Foundation of the Jiangsu Higher Education Institutions of China

Jiangsu Province "Innovative and Entrepreneurial Team" Program of China

National Key Research and Development Programs of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01921-20

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