Development of an Anti-Acinetobacter baumannii Biofilm Phage Cocktail: Genomic Adaptation to the Host-Reference-Cited by-同舟云学术

Development of an Anti-Acinetobacter baumannii Biofilm Phage Cocktail: Genomic Adaptation to the Host

Published:2022-03-15 Issue:3 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Blasco L.¹²^ORCID,Bleriot I.¹²,González de Aledo M.¹²,Fernández-García L.¹²,Pacios O.¹²,Oliveira H.³^ORCID,López M.¹²,Ortiz-Cartagena C.¹,Fernández-Cuenca F.⁴²⁵,Pascual Á.⁴²⁵,Martínez-Martínez L.⁶²⁵,Pachón J.⁷⁵,Azeredo J.³,Tomás M.¹²⁵^ORCID

Affiliation:

1. Microbiology Department-Research Institute Biomedical A Coruña (INIBIC); Hospital A Coruña (CHUAC); University of A Coruña (UDC), A Coruña, Spain

2. Study Group on Mechanisms of Action and Resistance to Antimicrobials (GEMARA) on the behalf of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)

3. Laboratório de Investigação em Biofilmes Rosário Oliveira (LIBRO), Centre of Biological Engineering (CEB), University of Minho, Braga, Portugal

4. Clinical Unit for Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen Macarena; Department of Microbiology and Medicine, University of Seville, Biomedicine Institute of Seville (IBIS), Seville, Spain

5. Spanish Network for Research in Infectious Diseases (REIPI) and CIBER de Enfermedades Infecciosas (CIBERINFEC), Carlos III Health Institute, Madrid, Spain

6. UGC Microbiología, Hospital Reina Sofía, Departamento de Química Agrícola, Edofología y Microbiología, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain

7. Clinical Unit for Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen Rocio; Department of Microbiology and Medicine; University of Seville, Biomedicine Institute of Seville (IBIS), Seville, Spain

Abstract

The need for alternatives to antibiotic therapy due to the emergence of multidrug resistant bacteria (MDR), such as the nosocomial pathogen Acinetobacter baumannii , has led to the recovery of phage therapy. In addition, phages can be combined in cocktails to increase the host range.

Funder

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01923-21

Reference65 articles.

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2. Global Challenge of Multidrug-Resistant Acinetobacter baumannii

3. Proteomic analysis of Acinetobacter baumannii in biofilm and planktonic growth mode