Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli-Reference-Cited by-同舟云学术

Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

El Zahed Sara S.¹²^ORCID,French Shawn¹²,Farha Maya A.¹²,Kumar Garima¹²,Brown Eric D.¹²^ORCID

Affiliation:

1. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

2. Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada

Abstract

Discovering new Gram-negative antibiotics has been a challenge for decades. This has been largely attributed to a limited understanding of the molecular descriptors governing Gram-negative permeation and efflux evasion.

Funder

Ontario Research Fund

Canada Research Chairs

Gouvernement du Canada | Canadian Institutes of Health Research

Canada Foundation for Innovation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01925-20

Reference50 articles.

1. The Science of Antibiotic Discovery

2. Antibacterial drug discovery in the resistance era

3. WHO. 2017. Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis. World Health Organization, Geneva, Switzerland.

4. CDC. 2019. Antibiotic resistance threats in the United States, 2019. US Department of Health and Human Services, CDC, Atlanta, GA.

5. WHO. 2019. 2019 antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline. World Health Organization, Geneva, Switzerland.

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis, and in vitro biological evaluation of meta-sulfonamidobenzamide-based antibacterial LpxH inhibitors;European Journal of Medicinal Chemistry;2024-11

2. The inactivation of tolC sensitizes Escherichia coli to perturbations in lipopolysaccharide transport;iScience;2024-05

3. A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor;Cell Reports;2024-04

4. Multidrug efflux in Gram-negative bacteria: structural modifications in active compounds leading to efflux pump avoidance;npj Antimicrobials and Resistance;2024-03-16

5. Preparation and characterization of new salts of tioconazole. Comparison of their dissolution performance;International Journal of Pharmaceutics;2024-03