Predicting Antimicrobial Resistance Using Partial Genome Alignments

Author:

Aytan-Aktug D.1ORCID,Nguyen M.23,Clausen P. T. L. C.1ORCID,Stevens R. L.245,Aarestrup F. M.1,Lund O.1ORCID,Davis J. J.236ORCID

Affiliation:

1. National Food Institute, Technical University of Denmark, Kongens Lyngby, Denmark

2. Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA

3. Data Science and Learning Division, Argonne National Laboratory, Argonne, Illinois, USA

4. Computing Environment and Life Sciences Directorate, Argonne National Laboratory, Argonne, Illinois, USA

5. Department of Computer Science, University of Chicago, Chicago, Illinois, USA

6. Northwestern Argonne Institute for Science and Engineering, Evanston, Illinois, USA

Abstract

Antimicrobial resistance causes thousands of deaths annually worldwide. Understanding the regions of the genome that are involved in antimicrobial resistance is important for developing mitigation strategies and preventing transmission.

Funder

DOD | Defense Advanced Research Projects Agency

HHS | NIH | National Institute of Allergy and Infectious Diseases

Novo Nordisk Fonden

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Reference66 articles.

1. CDC. 2019. Antibiotic resistance threats in the United States. CDC, U.S. Department of Health and Human Services, Atlanta, GA.

2. European Centre for Disease Prevention and Control. 2020. Antimicrobial resistance in the EU/EEA (EARS-Net)—annual epidemiological report 2019. Stockholm, Sweden.

3. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem

4. Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

5. Sequencing-based methods and resources to study antimicrobial resistance

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