Antimicrobial Chemicals Associate with Microbial Function and Antibiotic Resistance Indoors

Author:

Fahimipour Ashkaan K.1,Ben Maamar Sarah2,McFarland Alexander G.2,Blaustein Ryan A.2,Chen Jing34,Glawe Adam J.2,Kline Jeff156,Green Jessica L.1678,Halden Rolf U.39,Van Den Wymelenberg Kevin156,Huttenhower Curtis1011,Hartmann Erica M.12ORCID

Affiliation:

1. Biology and the Built Environment Center, University of Oregon, Eugene, Oregon, USA

2. Department of Civil and Environmental Engineering, Northwestern University, Evanston, Illinois, USA

3. Biodesign Center for Environmental Health Engineering, Biodesign Institute, Arizona State University, Tempe, Arizona, USA

4. School for Biological Health Systems Engineering, Arizona State University, Tempe, Arizona, USA

5. Energy Studies in Buildings Laboratory, University of Oregon, Eugene, Oregon, USA

6. Institute for Health in the Built Environment, University of Oregon, Portland, Oregon, USA

7. Institute of Ecology & Evolution, University of Oregon, Eugene, Oregon, USA

8. Santa Fe Institute, Santa Fe, New Mexico, USA

9. School of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, Arizona, USA

10. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA

11. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA

Abstract

The ubiquitous use of antimicrobial chemicals may have undesired consequences, particularly on microbes in buildings. This study shows that the taxonomy and function of microbes in indoor dust are strongly associated with antimicrobial chemicals—more so than any other feature of the buildings. Moreover, we identified links between antimicrobial chemical concentrations in dust and culturable bacteria that are cross-resistant to three clinically relevant antibiotics. These findings suggest that humans may be influencing the microbial species and genes that are found indoors through the addition and removal of particular antimicrobial chemicals.

Funder

Alfred P. Sloan Foundation

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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