Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities-Reference-Cited by-同舟云学术

Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities

Published:2021-06-29 Issue:3 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Du Jingjie¹,Zayed Ahmed A.¹²,Kigerl Kristina A.³⁴⁵²^ORCID,Zane Kylie⁶,Sullivan Matthew B.¹⁷⁸²,Popovich Phillip G.³⁴⁵²^ORCID

Affiliation:

1. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

2. Center of Microbiome Science, The Ohio State University, Columbus, Ohio, USA

3. Department of Neuroscience, The Ohio State University College of Medicine, Columbus, Ohio, USA

4. The Belford Center for Spinal Cord Injury, The Ohio State University College of Medicine, Columbus, Ohio, USA

5. The Center for Brain and Spinal Cord Repair, The Ohio State University College of Medicine, Columbus, Ohio, USA

6. Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, Ohio, USA

7. Department of Civil, Environmental and Geodetic Engineering, The Ohio State University, Columbus, Ohio, USA

8. Infectious Disease Institute, The Ohio State University, Columbus, Ohio, USA

Abstract

To our knowledge, this is the first article to apply metagenomics to characterize changes in gut microbial population dynamics caused by a clinically relevant model of central nervous system (CNS) trauma. It also utilizes the most current approaches in genome-resolved metagenomics and viromics to maximize the biological inferences that can be made from these data.

Funder

Belford Center for Spinal Cord Injury

Ray W Poppleton Research Endowment

Gordon and Betty Moore Foundation

HHS | NIH | National Institute of Neurological Disorders and Stroke

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.01356-20

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