Plasmids Shape the Current Prevalence of tmexCD1-toprJ1 among Klebsiella pneumoniae in Food Production Chains-Reference-Cited by-同舟云学术

Plasmids Shape the Current Prevalence of tmexCD1-toprJ1 among Klebsiella pneumoniae in Food Production Chains

Published:2021-10-26 Issue:5 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Peng Kai¹²,Wang Qian¹²,Yin Yi¹²,Li Yan¹²,Liu Yuan¹²³^ORCID,Wang Mianzhi¹²³,Qin ShangShang⁴⁵^ORCID,Wang Zhiqiang¹²,Li Ruichao¹²³^ORCID

Affiliation:

1. College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China

2. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu Province, People’s Republic of China

3. Institute of Comparative Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China

4. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China

5. Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China

Abstract

Tigecycline, the first member of the glycylcycline class of antibacterial agents, is frequently used to treat complicated infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. The emergence of a novel plasmid-mediated efflux pump, TmexCD1-ToprJ1, conferring resistance to multiple antimicrobials, including tigecycline, poses a huge risk to human health.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Postgraduate Research & Practice Innovation Program of Jiangsu Province

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00702-21

Reference56 articles.

1. Antimicrobial Resistance: a One Health Perspective

2. Tackling antibiotic resistance: the environmental framework

3. Mobile Genetic Elements Associated with Antimicrobial Resistance

4. Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence

5. Biology of Three ICE Families: SXT/R391, ICE Bs1 , and ICE St1 /ICE St3

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Global genomic epidemiology and transmission dynamics of plasmid-borne tmexCD-toprJ-carrying Klebsiella pneumoniae in a one health context;Science of The Total Environment;2024-11

2. Discovery and characterization of tmexCD3-toprJ1 on a plasmid from Pseudomonas putida isolated in a public trash can;Microbiology Spectrum;2024-08-20

3. Large-scale bacterial genomic and metagenomic analysis reveals Pseudomonas aeruginosa as potential ancestral source of tigecycline resistance gene cluster tmexCD-toprJ;Microbiological Research;2024-08

4. Global evolutionary dynamics of virulence genes in ST11-KL47 carbapenem-resistant Klebsiella pneumoniae;International Journal of Antimicrobial Agents;2024-08

5. Co-existence of two plasmids harboring transferable resistance-nodulation-division pump gene cluster, tmexCD1-toprJ1, and colistin resistance gene mcr-8 in Klebsiella pneumoniae;Annals of Clinical Microbiology and Antimicrobials;2024-07-26