Butyrate Producers as Potential Next-Generation Probiotics: Safety Assessment of the Administration of Butyricicoccus pullicaecorum to Healthy Volunteers

Author:

Boesmans Leen1,Valles-Colomer Mireia23ORCID,Wang Jun23,Eeckhaut Venessa4,Falony Gwen23,Ducatelle Richard4,Van Immerseel Filip4,Raes Jeroen235,Verbeke Kristin16

Affiliation:

1. Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium

2. Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium

3. Center for Microbiology, VIB, Leuven, Belgium

4. Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

5. Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium

6. Leuven Food Science and Nutrition Research Center, KU Leuven, Leuven, Belgium

Abstract

This study is the first to determine the safety and tolerance in humans of a butyrate-producing Clostridium cluster IV next-generation probiotic. Advances in gut microbiota research have triggered interest in developing colon butyrate producers as next-generation probiotics. Butyricicoccus pullicaecorum 25-3 T is one such potential probiotic, with demonstrated safety in vitro as well as in animal models. Here, we produced an encapsulated B. pullicaecorum formulation that largely preserved its viability over an 8-month storage period at 4°C. Administration of this formulation to healthy volunteers allowed us to establish the intervention as safe and well tolerated. The probiotic intervention did not cause disruptive alterations in the composition or metabolic activity of health-associated microbiota. The results presented pave the way for the exploration of the impact of the strain on microbiota alterations in a clinical setting.

Funder

Rega Institute

KU Leuven

Vlaams Instituut voor Biotechnologie

Fonds Wetenschappelijk Onderzoek

Agentschap Innoveren en Ondernemen

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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