Recurrent Vulvovaginal Candidiasis: a Dynamic Interkingdom Biofilm Disease of Candida and Lactobacillus

Author:

McKloud Emily1,Delaney Christopher1,Sherry Leighann2,Kean Ryan3,Williams Shanice1,Metcalfe Rebecca4,Thomas Rachael4,Richardson Riina5ORCID,Gerasimidis Konstantinos1,Nile Christopher J.6,Williams Craig1,Ramage Gordon1ORCID

Affiliation:

1. School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, Glasgow, UK

2. School of Life Sciences, Glasgow, UK

3. Department of Biological and Biomedical Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK

4. Sandyford Sexual Health Service, NHS Greater Glasgow and Clyde, Glasgow, UK

5. Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

6. School of Dental Sciences, University of Newcastle, Newcastle upon Tyne, UK

Abstract

RVVC is a significant burden, both economically and for women's health, but its prevalence is poorly documented globally due to the levels of self-treatment. Identifying triggers for development and recurrence of VVC and the pathogenesis of the microbes involved could considerably improve prevention and treatment options for women with recurrent, azole-resistant cases.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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