Oral Microbiome Alterations Associated with Early Childhood Caries Highlight the Importance of Carbohydrate Metabolic Activities

Author:

Wang Yuan1,Wang Sa1,Wu Chunyan23,Chen Xi1,Duan Zhuhui1,Xu Qian3,Jiang Wen1,Xu Lei1,Wang Tingting3,Su Lingkai1,Wang Ying1,Chen Yadong1,Zhang Jie1,Huang Yun3,Tong Suman1,Zhou Cheng4,Deng Shuli1,Qin Nan234

Affiliation:

1. Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, Zhejiang University School of Medicine, Hangzhou, China

2. Shanghai Tenth People’s Hospital Affiliated to Tongji University, Shanghai, China

3. Realbio Genomics Institute, Shanghai, China

4. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Abstract

Dental caries is a highly prevalent oral disease that can lead to severe dental damage and may greatly compromise the quality of life of the affected individuals. Previous studies, including those based on 16S rRNA gene, have revealed that the oral microbiota plays a prominent role in development of the disease. But the approach of those studies was limited in analyzing several key microbiome traits, including species- or strain-level composition and functional profile. Here, we performed metagenomic analyses for a cohort of preschool children with or without caries. Our results showed that caries was associated with extensive microbiota differences at various taxonomic and functional levels. Some caries-associated species had not been previously reported, some of which may have significant clinical implications. A microbiome gene catalogue from children with caries was constructed for the first time. The results demonstrated that caries is associated with alterations of the oral microbiome, including changes in microbial composition and metabolic functional profile.

Funder

China State Key Clinical Department of China

General project of health and family planning commission of zhejiang province

Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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