Computational Model To Quantify the Growth of Antibiotic-Resistant Bacteria in Wastewater

Author:

Sutradhar Indorica1ORCID,Ching Carly1,Desai Darash1,Suprenant Mark1,Briars Emma23,Heins Zachary13,Khalil Ahmad S.134,Zaman Muhammad H.15ORCID

Affiliation:

1. Department of Biomedical Engineering, Boston University, Boston, Massachusetts, USA

2. Department of Bioinformatics, Boston University, Boston, Massachusetts, USA

3. Biological Design Center, Boston University, Boston, Massachusetts, USA

4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA

5. Howard Hughes Medical Institute, Boston University, Boston, Massachusetts, USA

Abstract

The rate at which antimicrobial resistance (AMR) has developed and spread throughout the world has increased in recent years, and according to the Review on Antimicrobial Resistance in 2014, it is suggested that the current rate will lead to AMR-related deaths of several million people by 2050 (Review on Antimicrobial Resistance, Tackling a Crisis for the Health and Wealth of Nations , 2014). One major reservoir of resistant bacterial populations that has been linked to outbreaks of drug-resistant bacterial infections but is not well understood is in wastewater settings, where antibiotic pollution is often present.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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