Pangenome Analytics Reveal Two-Component Systems as Conserved Targets in ESKAPEE Pathogens-Reference-Cited by-同舟云学术

Pangenome Analytics Reveal Two-Component Systems as Conserved Targets in ESKAPEE Pathogens

Published:2021-02-23 Issue:1 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

Rajput Akanksha¹^ORCID,Seif Yara¹^ORCID,Choudhary Kumari Sonal¹^ORCID,Dalldorf Christopher¹,Poudel Saugat¹^ORCID,Monk Jonathan M.¹^ORCID,Palsson Bernhard O.¹²³⁴^ORCID

Affiliation:

1. Systems Biology Research Group, Department of Bioengineering, University of California, San Diego, San Diego, California, USA

2. Bioinformatics and Systems Biology Program, University of California, San Diego, San Diego, California, USA

3. Department of Pediatrics, University of California, San Diego, San Diego, California, USA

4. Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, Kongens, Lyngby, Denmark

Abstract

The ESKAPEE pathogens are the leading cause of health care-associated infections worldwide. Two-component systems (TCSs) can be used as effective targets against pathogenic bacteria since they are ubiquitous and manage various vital functions such as antibiotic resistance, virulence, biofilms, quorum sensing, and pH balance, among others.

Funder

Novo Nordisk Fonden

HHS | NIH | OSC | Common Fund

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00981-20

Reference51 articles.

1. Signal integration in bacterial two-component regulatory systems

2. Families of bacterial signal-transducing proteins

3. Molecular Mechanisms of Two-Component Signal Transduction

4. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity;Microbiology Spectrum;2024-08-06

2. The mobilome landscape of biocide-resistance in Brazilian ESKAPE isolates;Brazilian Journal of Microbiology;2024-07-19

3. Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases;The Journal of Antibiotics;2024-06-25

4. The Pangenome ofEscherichia coli;2024-06-08

5. Engineered endolysin of Klebsiella pneumoniae phage is a potent and broad-spectrum bactericidal agent against “ESKAPEE” pathogens;Frontiers in Microbiology;2024-05-09