Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium

Author:

Ziesack Marika1ORCID,Gibson Travis2,Oliver John K. W.1,Shumaker Andrew M.1,Hsu Bryan B.3,Riglar David T.13,Giessen Tobias W.3,DiBenedetto Nicholas V.2,Bry Lynn2,Way Jeffrey C.1,Silver Pamela A.13,Gerber Georg K.2

Affiliation:

1. Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, Massachusetts, USA

2. Massachusetts Host-Microbiome Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

Microbial communities are ubiquitous in nature. Bacterial consortia live in and on our body and in our environment, and more recently, biotechnology is applying microbial consortia for bioproduction. As part of our body, bacterial consortia influence us in health and disease. Microbial consortium function is determined by its composition, which in turn is driven by the interactions between species. Further understanding of microbial interactions will help us in deciphering how consortia function in complex environments and may enable us to modify microbial consortia for health and environmental benefits.

Funder

DARPA BRICS

HHS | National Institutes of Health

Harvard Digestive Disease Center

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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