Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?

Author:

Lopes Ralf1ORCID,Fuentes-Castillo Danny23ORCID,Fontana Herrison34ORCID,Rodrigues Larissa34,Dantas Karine1,Cerdeira Louise5ORCID,Henriques Isabel67ORCID,Lincopan Nilton134ORCID

Affiliation:

1. Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

2. Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil

3. One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil

4. Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil

5. Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia

6. Centre for Environmental and Marine Studies (CESAM), University of Aveiro, Aveiro, Portugal

7. Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal

Abstract

Extended-spectrum β-lactamases (ESBL)-producing Enterobacterales are a leading cause of human and animal infections, being classified as critical priority pathogens by the World Health Organization. Epidemiological studies have shown that spread of ESBL-producing bacteria is not a problem restricted to hospitals, but also represents a growing problem involving environmental and food safety.

Funder

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Bill and Melinda Gates Foundation

Centro de Estudos do Ambiente e do Mar

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

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